Disease Models & Mechanisms (DMM) is an online Open Access journal focusing on the use of model systems to better understand, diagnose and treat human disease.
The primary aim of DMM is to promote human health by inspiring collaboration between basic and clinical researchers in translational science, and the journal is committed to presenting rigorously peer-reviewed research that has significant translational impact. The interdisciplinary nature of DMM means that a diverse range of diseases, approaches and models fall within its broad scope. DMM is guided by an international team of expert research-active Editors, led by Monica Justice and Ross Cagan, and the journal is supported by an outstanding Editorial Advisory Board.
Marina Mione and colleagues provide insight into the role of YAP activation in MAPK- and PI3K-induced cancer using a new zebrafish brain tumor model.
Also in this issue, Diane Fatkin and co-authors apply high-frequency echocardiography in adult zebrafish to demonstrate how this technology can provide key insights into cardiac function, while Alexandra Joyner and co-authors provide compelling evidence for a tumor-suppressive role for hedgehog (HH) signalling in prostate cancer.
In this issue
Read a tribute to Susan Lindquist from DMM's founding Editor-in-Chief, Vivian Siegel.
Also in this issue, Jacob Albritton and Jordan Miller review the application of 3D bioprinting to generate in vitro cancer models that recapitulate the tumor microenvironment. Read other articles in our online Cancer Collection here.