Disease Models & Mechanisms (DMM) is an online Open Access journal focusing on the use of model systems to better understand, diagnose and treat human disease.
The primary aim of DMM is to promote human health by inspiring collaboration between basic and clinical researchers in translational science, and the journal is committed to presenting rigorously peer-reviewed research that has significant translational impact. The interdisciplinary nature of DMM means that a diverse range of diseases, approaches and models fall within its broad scope. DMM is guided by an international team of expert research-active Editors, led by Monica Justice and Ross Cagan, and the journal is supported by an outstanding Editorial Advisory Board.
Special issue highlights
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder causing muscle weakness and paralysis. Here, Javier Fernández-Ruiz and colleagues describe a new spontaneous canine model for ALS that offers several advantages over traditional transgenic small animal models in translation of therapeutic success to human ALS patients.
Also in this special issue on neurodegeneration, an At a Glance poster by Edward Lee and colleagues provides a detailed visual realisation of how impaired RNA metabolism can underlie the pathophysiology of neurodegeneration, and a Review from Gabriela Caraveo and colleagues presents the current evidence for dysregulation of calcium-dependent pathways in Parkinson’s disease.
DMM Founding Editor Huda Zoghbi describes in an interview how the cases she saw as a clinical neurologist inspired her to move into the lab, and why it has taken her 25 years to understand the biology of neurological disorders well enough to start developing therapeutics.
Also in DMM this month, a special issue Editorial by Aaron Gitler and James Shorter covers historical models in neurodegeneration research, the potential for future breakthroughs, and an introduction to the articles in the special issue.
News from DMM
Hearing loss affects one in six people in the UK and around 360 million people worldwide. This year, the UK Council on Deafness is co-ordinating Deaf Awareness Week from 15-21 May 2017, with a theme of ‘celebration’ of collaborative efforts to raise awareness, provide services for affected individuals and advance research into prevention of hearing loss. Joining the celebration of deafness-related research, Disease Models & Mechanisms (DMM) is pleased to present a selection of articles on disorders affecting the ear and hearing.
You can now submit your paper to DMM in any format. From now on, we will only ask you to do what is absolutely necessary at submission, with formatting requirements moving instead to the revision stages. As part of this change we are also removing the Materials and Methods section from our length limit to an article. Click here to read more.