Disease Models & Mechanisms (DMM) is an online Open Access journal focusing on the use of model systems to better understand, diagnose and treat human disease.
The primary aim of DMM is to promote human health by inspiring collaboration between basic and clinical researchers in translational science, and the journal is committed to presenting rigorously peer-reviewed research that has significant translational impact. The interdisciplinary nature of DMM means that a diverse range of diseases, approaches and models fall within its broad scope. DMM is guided by an international team of expert research-active Editors, led by Monica Justice and Ross Cagan, and the journal is supported by an outstanding Editorial Advisory Board.
Jaime Modiana and co-authors show that heterotypic mouse models of bone cancer developed using cell lines derived from canine tumors recapitulate the heterogeneous nature of the disease.
Also in this issue, Elaine Ostrander and colleagues provide an argument for the generation of breed-specific strategies for WGS and GWAS in dog populations, while Kevin Petrie et al. demonstrate that aberrant expression of HDAC9 in B cells promotes development of lymphoproliferative disease and lymphoma. The authors use microarray data analysis to generate an interaction network for upregulated genes in HDAC9 B-cell tumors.
Front Section Highlights
Ross Cagan, Senior Editor of DMM, gives basic researchers tips on how to enter the world of drug screening in this new Editorial. Check out other articles in our Model Systems in Drug Discovery collection here.
In the latest issue, John Mullins and colleagues review insights into renal pathophysiology and treatment based on rat studies. This article is the latest addition to our new collection focused on the rat as a model for human diseases, guest edited by Tim Aitman and Aron Geurts. The launch issue contained a series of reviews, an interview with Howard Jacob, and several new and exciting research papers, as described in the introductory Editorial.
News from the DMM team
Just announced from Washington D.C.
DMM Editor-in-Chief Monica Justice has been named a Fellow of the American Association for the Advancement of Science (AAAS): “For distinguished contributions to the genetics field, particularly for development of mouse as a model for identifying disease genes and elucidating therapies for human diseases.” Congratulations to Monica and the other new Fellows.